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Related Concept Videos

The Mammary Glands01:12

The Mammary Glands

The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Related Experiment Video

Updated: Jun 14, 2026

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
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Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Published on: June 7, 2019

Lobular breast carcinoma and its variants.

Emad A Rakha1, Ian O Ellis

  • 1Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham University, Nottingham, United Kingdom. emadrakha@yahoo.com

Seminars in Diagnostic Pathology
|March 24, 2010
PubMed
Summary

Lobular carcinoma, a rising breast cancer type, presents unique challenges in diagnosis and management. This review covers its subtypes, molecular pathology, and clinical outcomes.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Lobular carcinoma is a distinct breast cancer subtype with increasing incidence.
  • Infiltrating lobular carcinoma (ILC) and precursor lesions pose diagnostic and management challenges.
  • Recognizing rare variants like pleomorphic lobular carcinoma is crucial for tailored treatment.

Purpose of the Study:

  • To provide a comprehensive review of lobular carcinomas.
  • To focus on lobular in situ lesions, epidemiology, and ILC subtypes.
  • To detail diagnostic, molecular, and grading aspects of ILC.

Main Methods:

  • Literature review of lobular carcinoma research.
  • Analysis of epidemiological data.
  • Synthesis of molecular pathology findings.

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Last Updated: Jun 14, 2026

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Published on: June 7, 2019

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Main Results:

  • Lobular carcinoma exhibits unique clinical, morphologic, and molecular characteristics.
  • Diagnostic difficulties are common, especially in screening settings.
  • Specific variants may require distinct management strategies.

Conclusions:

  • A thorough understanding of lobular carcinoma subtypes and molecular features is essential.
  • Accurate diagnosis and tailored management are critical for patient outcomes.
  • Further research into rare variants and precursor lesions is warranted.