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Related Concept Videos

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

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Related Experiment Video

Updated: Jun 14, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Regulatory RNAs in brain function and disorders.

Anna Iacoangeli1, Riccardo Bianchi, Henri Tiedge

  • 1The Robert F. Furchgott Center for Neural and Behavioral Science, Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

Brain Research
|March 24, 2010
PubMed
Summary
This summary is machine-generated.

Regulatory RNAs (non-protein-coding RNAs) play key roles in brain function, influencing neuronal development and plasticity. Their dysregulation is linked to neurological disorders like epilepsy and neurodegeneration.

Related Experiment Videos

Last Updated: Jun 14, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Regulatory RNAs, a diverse group of non-protein-coding RNAs (npcRNAs), are crucial for cellular functions.
  • These molecules are increasingly recognized for their significant roles within neuronal systems.
  • Their mechanisms involve post-transcriptional gene regulation, impacting gene silencing and expression.

Purpose of the Study:

  • To review the established roles of regulatory RNAs in neuronal development, differentiation, and plasticity.
  • To explore the involvement of npcRNA dysregulation in various brain pathologies.
  • To highlight the importance of regulatory RNAs in understanding brain function and disease.

Main Methods:

  • Literature review of existing research on regulatory RNAs in neurons.
  • Analysis of studies investigating npcRNA function in neuronal processes.
  • Examination of evidence linking npcRNA dysregulation to neurological disorders.

Main Results:

  • Regulatory RNAs are integral to neuronal development, differentiation, and synaptic plasticity.
  • Evidence suggests npcRNAs modulate gene expression post-transcriptionally, affecting neuronal function.
  • Dysregulation of these RNAs is associated with neurodevelopmental disorders, neurodegeneration, and epilepsy.

Conclusions:

  • Regulatory RNAs are critical regulators of neuronal function and brain health.
  • Understanding npcRNA mechanisms and dysregulation offers insights into neurological diseases.
  • Further research into regulatory RNAs is essential for advancing neuroscience and developing therapeutic strategies.