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Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
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Building off-the-shelf tissue-engineered composites.

Timothy Burg1, Cheryl A P Cass, Richard Groff

  • 1Department of Electrical and Computer Engineering, Clemson University, Clemson, SC 29634, USA.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|March 24, 2010
PubMed
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Developing complex, heterogeneous tissues for drug discovery and disease research remains challenging. This paper details the hurdles in translating advanced biofabrication and tissue engineering concepts into viable, complex tissue-test systems.

Area of Science:

  • Bioengineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Personalized medicine advancements are hindered by slow clinical translation of tissue-engineered products.
  • Existing 3D tissue culture systems lack the complexity for developing heterogeneous tissues.
  • The promise of rapid biofabrication for complex organs faces significant technical and financial challenges.

Purpose of the Study:

  • To address the challenges in developing precision, heterogeneous complex tissue-test systems.
  • To explore the practical difficulties in translating advanced tissue engineering concepts into reality.
  • To use breast tissue as a case study for developing complex tissue-test systems for research.

Main Methods:

  • Combining rapid prototyping with tissue engineering technologies.

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Published on: April 11, 2017

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  • Developing heterogeneous complex tissue-test systems.
  • Focusing on the practical challenges encountered since 2003.

    • Main Results:

    • The translation of tissue-engineered products to the clinical market has been limited and financially unviable.
    • Rapid prototyping of whole organs faces challenges with large cellular volumes and intricate patterns.
    • Homogenous forms are often mislabeled as tissues, failing to represent native biological heterogeneity.

    Conclusions:

    • Significant challenges persist in creating viable, complex tissue-test systems for drug discovery and disease research.
    • The development of heterogeneous, functional tissue models requires overcoming substantial biofabrication and engineering hurdles.
    • The case study of breast tissue highlights the difficulties in achieving precision development of complex biological systems.