Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 14, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Decrease in breast density in the contralateral normal breast of patients receiving neoadjuvant chemotherapy: MR

Jeon-Hor Chen1, Ke Nie, Shadfar Bahri

  • 1John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California Irvine, Irvine Hall 164, Irvine, CA 92697, USA. jeonhc@uci.edu

Radiology
|March 24, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

The long non-coding RNA NEXUS arose from a chromosomal structural variation enhances drought tolerance through epigenetic regulation in allotetraploid cotton.

Plant communications·2026
Same author

Determination of HU override for gold fiducial markers in proton therapy.

Journal of applied clinical medical physics·2026
Same author

Triptolide enhances anti-cancer activities of irinotecan in human colon cancer HT-29 cells <i>in vitro</i> and HT-29 cell xenograft tumor model in nude mice.

Integrative cancer therapies·2026
Same author

Correction to: Response evaluations in non-small cell lung cancer patients undergoing immunotherapy: A comparative analysis of RECIST 1.1, iRECIST, and imRECIST criteria.

Medical oncology (Northwood, London, England)·2026
Same author

Palbociclib Enhances Radiation Therapy Efficacy by Promoting Apoptosis and Immune Modulation in Oral Squamous Cell Carcinoma.

International journal of radiation oncology, biology, physics·2026
Same journal

Erratum for: Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.

Radiology·2026
Same journal

Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

Radiology·2026
Same journal

Erratum for: Blue Rubber Bleb Nevus Syndrome.

Radiology·2026
Same journal

Redefining the Clinical Role of MRI in Endometrial Cancer Staging.

Radiology·2026
Same journal

To Ablate or Not to Ablate: The Colorectal Liver Metastasis Question.

Radiology·2026
Same journal

The Limits of Radiologic Categorization in Pulmonary Nonsolid Nodules.

Radiology·2026
See all related articles

Neoadjuvant chemotherapy significantly reduces breast density in patients, with effects more pronounced in younger individuals. Quantitative MRI reveals these changes after initial treatment cycles.

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Neoadjuvant chemotherapy (NAC) is a common treatment for breast cancer.
  • Changes in breast density can occur during chemotherapy.
  • Quantitative magnetic resonance (MR) imaging offers a precise method to assess these changes.

Purpose of the Study:

  • To evaluate changes in breast density using quantitative MR imaging.
  • To assess the contralateral normal breast in patients undergoing neoadjuvant chemotherapy.
  • To determine the impact of specific chemotherapy regimens (AC, AC plus taxane) and age on breast density reduction.

Main Methods:

  • Quantitative MR imaging-based segmentation was used to analyze breast density.
  • 54 breast cancer patients receiving NAC were studied.

More Related Videos

Clinical Imaging of Microwave Mammography
05:28

Clinical Imaging of Microwave Mammography

Published on: November 14, 2025

Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
10:13

Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment

Published on: June 21, 2022

Related Experiment Videos

Last Updated: Jun 14, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Clinical Imaging of Microwave Mammography
05:28

Clinical Imaging of Microwave Mammography

Published on: November 14, 2025

Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
10:13

Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment

Published on: June 21, 2022

  • Multivariate regression analysis investigated age-related differences in density change.

    • Main Results:

    • Breast density decreased by a mean of 10% after AC and 12.7% after AC plus taxane.
    • Density reduction was significant after one to two cycles of AC (-9.4%) and more pronounced after four cycles (-14.7%).
    • Younger patients (<40 years) experienced greater density reduction than older patients (>55 years).

    Conclusions:

    • Three-dimensional MR imaging demonstrates significant breast density reduction in patients undergoing chemotherapy.
    • The reduction in breast density is evident even after the initial cycles of the AC regimen.
    • Age is a significant factor influencing the degree of chemotherapy-induced breast density reduction.