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Pregnancy and cystic fibrosis
G J Canny1, M Corey, R A Livingstone
1Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Obstetrics and Gynecology
|June 1, 1991
Summary
Pregnancy in cystic fibrosis patients is increasingly common. This study found that most patients, especially those who are pancreatic-sufficient, tolerated pregnancy well with minimal impact on their health.
Area of Science:
- Reproductive Medicine
- Pulmonology
- Genetics
Background:
- Increasing number of cystic fibrosis (CF) patients are reaching reproductive age.
- Reduced fertility in CF is often overcome, leading to more pregnancies.
- Previous literature suggested significant risks associated with pregnancy in CF patients.
Purpose of the Study:
- To evaluate the tolerability and impact of pregnancy on patients with cystic fibrosis.
- To assess maternal health outcomes, including pulmonary and nutritional status.
- To determine neonatal outcomes such as prematurity, mortality, and congenital abnormalities.
Main Methods:
- Retrospective review of 38 pregnancies in 25 female patients with cystic fibrosis.
- Analysis of maternal health parameters (pulmonary, nutritional status).
- Evaluation of pregnancy outcomes, including need for therapeutic abortion and neonatal data.
Main Results:
- Pregnancy was well tolerated by most CF patients.
- Little to no significant negative impact on maternal pulmonary or nutritional status was observed.
- Low incidence of prematurity and neonatal mortality; no congenital abnormalities reported.
- Pancreatic-sufficient patients showed particular tolerance.
Conclusions:
- Pregnancy is generally well-tolerated in the majority of cystic fibrosis patients.
- The risk of adverse outcomes appears lower than previously suggested, especially for pancreatic-sufficient individuals.
- Careful monitoring allows for successful pregnancy management in CF patients.