Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Insomnia01:27

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Continuous Positive Airway Pressure on Central and Peripheral Blood Pressure in Patients with Uncontrolled Hypertension and Obstructive Sleep Apnea: The Randomized Controlled MORPHEOS Clinical Trial.

Annals of the American Thoracic Society·2025
Same author

Bacterial flotillins as destabilizers of phospholipid membranes.

Biochimica et biophysica acta. Biomembranes·2024
Same author

Effect of antihypertensive agents on sleep apnea and ambulatory blood pressure in patients with hypertension: A randomized controlled trial.

Sleep medicine·2024
Same author

Cheeks appearance as a novel predictor of obstructive sleep apnea: the CASA score study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2024
Same author

Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure.

Communications biology·2023
Same author

Effects of chlorthalidone plus amiloride compared with amlodipine on short-term blood pressure variability in individuals with hypertension and obstructive sleep apnea: a randomized controlled trial.

Blood pressure monitoring·2023
Same journal

In conversation with Dr Harlan M. Krumholz: On preprints, the story behind medRxiv.

The Indian journal of medical research·2026
Same journal

Clay pots for reducing fluoride concentration in drinking water.

The Indian journal of medical research·2026
Same journal

Telephonic reminders for improving anti-rabies vaccination completion at a rural primary health centre: A quality improvement initiative.

The Indian journal of medical research·2026
Same journal

BMI-dependent methylation and clinical signatures in North Indian women with PCOS.

The Indian journal of medical research·2026
Same journal

Focused ultrasound-induced blood-brain barrier modulation for drug delivery in recurrent glioblastoma: A systematic review.

The Indian journal of medical research·2026
Same journal

Prevalence of metabolic dysfunction associated steatotic liver disease in type 2 diabetes mellitus in India: A systematic review and meta-analysis.

The Indian journal of medical research·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Circadian rhythm sleep disorders.

Denis Martinez1, Maria do Carmo Sfreddo Lenz

  • 1Division of Cardiology, Hospital de Clínicas de Porto Alegre, UFRGS, Rua Ramiro Barcelos, CEP , Brazil. dm@ufrgs.br

The Indian Journal of Medical Research
|March 24, 2010
PubMed
Summary
This summary is machine-generated.

Circadian rhythm sleep disorders disrupt the body

More Related Videos

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jun 14, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Area of Science:

  • Sleep Medicine
  • Chronobiology
  • Neurology

Background:

  • Circadian rhythm sleep disorders (CRSDs) involve a misalignment between the internal biological clock and the external 24-hour environment.
  • Common CRSDs include delayed sleep phase (adolescents) and advanced sleep phase (elderly).
  • Disruptions in light-dark cycles, affecting blind individuals and shift workers, increase CRSD risk.

Purpose of the Study:

  • To review circadian rhythm syndromes within the International Classification of Sleep Disorders.
  • To present updated diagnostic and treatment guidelines for CRSDs.

Main Methods:

  • Literature review of circadian rhythm sleep disorders.
  • Analysis of diagnostic criteria from the International Classification of Sleep Disorders.
  • Synthesis of current treatment guidelines.

Main Results:

  • Nine distinct circadian rhythm sleep disorders are clinically relevant.
  • Delayed and advanced sleep phase disorders are the most prevalent.
  • Light exposure is a critical factor in circadian rhythm regulation.

Conclusions:

  • Accurate diagnosis and timely treatment of CRSDs are essential.
  • Understanding circadian biology is key to managing these sleep disorders.
  • Updated guidelines aid in the clinical management of CRSDs.