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Published on: August 16, 2024
Mechanisms of vascular stability and the relationship to human disease
Matthew C P Smith1, Dean Y Li, Kevin J Whitehead
1Molecular Medicine Program, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA.
Purpose Of Review:
The genetic basis for a variety of vascular malformation syndromes have been described, with an increasing functional understanding of the associated genes.
Recent Findings:
Genes responsible for familial vascular malformation syndromes have increasingly been shown to be involved in the control of vascular stability.
Summary:
Genes involved in vascular stability pathways are good candidates for causing vascular malformation syndromes. Although these findings confirm the biologic importance of the involved pathways, further explanations are required to describe the focal nature of disease.
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