Related Experiment Video
Updated: Jun 14, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
Ontogeny and homeostasis of Langerhans cells
Florent Ginhoux1, Miriam Merad
1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Immunos, Biopolis, Singapore. florent_ginhoux@immunol.a-star.edu.sg
Abstract:
Langerhans cells (LCs) refer to the dendritic cells (DCs) that populate the epidermis. Strategically located at one of the body's largest interfaces with the external environment, they form the first line of defense against pathogens that breach the skin. Although LCs share several phenotypical and functional features with lymphoid and non-lymphoid organ DCs, they also have unique properties that distinguish them from most DC populations. In this review, we will discuss the key mechanisms that regulate LC homeostasis in quiescent and inflamed skin. We will also discuss recent evidence that suggests that LCs arise from dedicated precursors during early embryonic development.
Related Concept Videos
Cells of the Adaptive Immune Response
Tissue Renewal without Stem Cells
However, failure of such a system...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Regulation of Hematopoietic Stem Cells
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Hematopoiesis
