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Related Concept Videos

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...

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Related Experiment Video

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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

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Published on: August 9, 2022

Two-step solid lipid extrusion as a process to modify dissolution behavior.

Maike Windbergs1, Sinan Gueres, Clare J Strachan

  • 1Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Düsseldorf, Germany.

AAPS Pharmscitech
|March 24, 2010
PubMed
Summary
This summary is machine-generated.

Controlled release oral dosage forms were created using tripalmitin and polyethylene glycol. Two-step extrusion significantly modified drug dissolution rates, offering a new method for drug delivery system development.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Developing oral dosage forms with controlled release characteristics is crucial for effective drug delivery.
  • Tripalmitin (a triglyceride) and polyethylene glycol (a hydrophilic polymer) were utilized as matrix formers.
  • Hydrophobic drugs require specific formulation strategies to ensure appropriate dissolution and bioavailability.

Purpose of the Study:

  • To investigate the influence of varying ratios of tripalmitin and polyethylene glycol on drug dissolution.
  • To explore the effect of a two-step extrusion process on extrudate structure and drug release.
  • To determine if two-step solid lipid extrusion can modify the dissolution behavior of oral dosage forms.

Main Methods:

  • Oral dosage forms were produced using varying ratios of tripalmitin and polyethylene glycol as matrix formers.
  • A hydrophobic model drug, chloramphenicol, was incorporated into the extrudates.
  • A two-step extrusion process was employed, involving initial extrusion, milling, and a second extrusion step.
  • Drug dissolution rates were measured and compared between one-step and two-step extrusion methods.

Main Results:

  • Increasing the content of polyethylene glycol in the matrix formers led to a higher drug release rate.
  • Two-step extrusion with initial polyethylene glycol extrusion enhanced dissolution rates.
  • Two-step extrusion with initial tripalmitin extrusion decreased dissolution rates compared to one-step extrusion.
  • The extrusion process significantly impacted the structure and drug dissolution of the extrudates.

Conclusions:

  • The ratio of matrix formers (tripalmitin and polyethylene glycol) directly influences drug dissolution.
  • Two-step solid lipid extrusion is an effective technique for modifying the dissolution behavior of oral dosage forms.
  • This process offers a viable strategy for tailoring drug release profiles in pharmaceutical formulations.