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Updated: Feb 22, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
[Skin and eyes]
E Kohl1, J Hillenkamp, M Landthaler
1Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Regensburg. Elisabeth.Kohl@klinik.uni-regensburg.de
Abstract:
Numerous diseases affect both skin and eyes due to similar ontogenetic origin. The eye is the second most common site of melanoma after the skin. The eyelids are predisposed for development of toxic and allergic dermatitis as the skin in this region is four times thinner than the other facial skin. The differential diagnosis must include atopic and seborrhoeic eyelid dermatitis. Atopic and vernal keratoconjunctivitis are associated with atopic eczema. Various immunobullous disorders involve the conjunctiva with varying severity. Side effects of dermatologic treatments with glucocorticoids, antimalarials, psoralens, retinoids, or tetracyclines may involve the eye.
Insights
Skin and eye diseases are linked due to shared origins. Eyelid skin
Area of Science:
- Ophthalmology and Dermatology
- Immunology
- Medical Science
Context:
- Skin and eye conditions often share common origins.
- Eyelid skin is particularly susceptible to dermatitis due to its thinness.
- Ocular manifestations are frequent in various dermatological diseases.
Purpose:
- To highlight the interconnectedness of skin and eye diseases.
- To emphasize the diagnostic considerations for eyelid conditions.
- To review potential ocular side effects of dermatologic treatments.
Summary:
- Diseases affecting skin and eyes are common due to shared developmental origins.
- The eyelids are prone to toxic and allergic dermatitis, requiring differential diagnosis with atopic and seborrhoeic eyelid dermatitis.
- Ocular involvement can occur in various dermatological conditions, including immunobullous disorders, and as side effects of treatments like glucocorticoids and retinoids.
Impact:
- Enhances understanding of the relationship between dermatological and ophthalmological conditions.
- Informs differential diagnosis for eyelid and ocular complaints.
- Raises awareness of potential ocular side effects from systemic dermatologic therapies.
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