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Related Experiment Video

Updated: Jun 14, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Laboratory tests for protein C deficiency.

Bernard Khor¹, Elizabeth M Van Cott

¹Department of Pathology, Massachusetts General Hospital, Boston, 02114, USA.

American Journal of Hematology

|March 24, 2010

Summary

This summary is machine-generated.

Hereditary protein C deficiency increases venous thrombosis risk. Testing involves activity assays, but acquired deficiency is common, requiring careful interpretation to distinguish hereditary cases and identify false negatives.

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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

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Published on: January 29, 2014

Area of Science:

Hematology
Clinical Chemistry
Genetics

Background:

Hereditary protein C deficiency is a genetic disorder causing a hypercoagulable state.
This condition elevates the risk of venous thromboembolism (VTE).
Acquired protein C deficiency is more prevalent than hereditary forms.

Purpose of the Study:

To outline diagnostic strategies for hereditary protein C deficiency.
To differentiate hereditary deficiency from acquired causes when protein C activity is low.
To identify factors that can lead to falsely normal protein C assay results.

Main Methods:

Review of current protein C activity (functional) assay methodologies, including clotting time and chromogenic assays.
Discussion of the advantages and disadvantages of different testing options.
Description of diagnostic algorithms for investigating low protein C activity.

Main Results:

Protein C activity assays are the recommended initial diagnostic step.
Acquired conditions necessitate careful evaluation to rule out hereditary deficiency.
Lupus anticoagulants and direct thrombin inhibitors can cause falsely normal results, masking true deficiency.

Conclusions:

Accurate diagnosis of hereditary protein C deficiency relies on appropriate assay selection and interpretation.
Distinguishing hereditary from acquired deficiency is crucial for patient management and VTE risk assessment.
Awareness of interfering factors is essential for reliable protein C testing.