Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sensitization by platelet transfusion.

A Brand1

  • 1Immunohaematologie en Bloedbank, Academisch Ziekenhuis, Leiden, Holland.

Schweizerische Medizinische Wochenschrift
|March 30, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Value of Routine Pelvic Examination in the Follow-Up of Patients Receiving Adjuvant Radiation Therapy for Endometrial Cancer: An Australian Tertiary-Centre Experience.

Journal of medical imaging and radiation oncology·2025
Same author

Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.

Journal of dental research·2024
Same author

Medical graphics to improve patient understanding and anxiety in elderly and cognitively impaired patients scheduled for transcatheter aortic valve implantation (TAVI).

Clinical research in cardiology : official journal of the German Cardiac Society·2023
Same author

Informed Consent before coronary angiography and percutaneous coronary intervention from the patient's perspective: A picture is worth a thousand words.

International journal of cardiology. Heart & vasculature·2022
Same author

Review of indications for immunoglobulin (IG) use: Narrowing the gap between supply and demand.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2020
Same author

A nurse- and peer-led psycho-educational intervention to support women with gynaecological cancers receiving curative radiotherapy: The PeNTAGOn randomised controlled trial - ANZGOG 1102.

Gynecologic oncology·2020
Same journal

Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

Schweizerische medizinische Wochenschrift·2010
Same journal

Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

Schweizerische medizinische Wochenschrift·2010
Same journal

Boeck's disease as a tuberculous syndrome.

Schweizerische medizinische Wochenschrift·2010
Same journal

Enteral primary tubercular complexes

Schweizerische medizinische Wochenschrift·2010
Same journal

Tuberculous stenoses of the large bronchi.

Schweizerische medizinische Wochenschrift·2010
Same journal

About the enzyme action.

Schweizerische medizinische Wochenschrift·2010
See all related articles

Rigorous white cell depletion of blood components can prevent HLA-antigen alloimmunization in patients without prior transfusions or pregnancy. However, presensitized patients remain at risk due to residual HLA-class I antigens.

Area of Science:

  • Immunology
  • Transfusion Medicine

Background:

  • Alloimmunization to HLA-antigens poses a risk in patients receiving blood products.
  • Previous blood transfusions or pregnancies can sensitize individuals to HLA-antigens.

Purpose of the Study:

  • To evaluate the effectiveness of white cell depletion in preventing HLA-antigen alloimmunization.
  • To identify remaining risks for presensitized patients.

Main Methods:

  • Analysis of current knowledge on white cell depletion strategies for blood components.
  • Assessment of alloimmunization risk in different patient populations.

Main Results:

  • White cell depletion before storage, omitting bedside filtration, virtually prevents alloimmunization in naive patients.

Related Experiment Videos

  • Presensitized patients face a significant risk of secondary antibody response due to residual HLA-class I antigens.

    • Conclusions:

    • Strict white cell depletion protocols are crucial for preventing de novo alloimmunization.
    • Alternative strategies are needed to mitigate alloimmunization risk in HLA-sensitized individuals.