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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Articles linked to this work by shared authors, journal, and citation graph.

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Ultrastructure of hepatic mitochondria in a child with hyperornithinemia, hyperammonemia, and homocitrullinuria.

Human pathology·1981
Same author

Ornithine methyl ester. An unusual metabolite encountered in the urine of patients with a urea cycle disorder characterized by hyperammonemia, hyperornithinemia and homocitrullinuria.

Clinical biochemistry·1977
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Letter: Locked wards in Canadian mental hospitals.

Canadian Medical Association journal·1976
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Hyperammonemia (ornithinemia) presenting as a unilateral cerebral mass lesion.

Surgical neurology·1976
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Proceedings: Hepatic ultrastructure in a child with carbamyl phosphate synthetase deficiency, hyperornithinaemia, hyperammonaemia, and homocitrullinuria.

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Leukocyte urea cycle enzymes in hyperammonemia.

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Can treatment be compulsory?

P D Gatfield

    Canadian Medical Association Journal
    |March 24, 2010
    PubMed
    Summary

    No abstract available in PubMed .

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