Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Large cell lymphoma stage IA/IAE.

H Nussbaum1, C Koo, A R Kagan

  • 1Department of Radiation Oncology, Southern California Permanente Medical Group, Los Angeles.

American Journal of Clinical Oncology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutaneous markers in ochronosis.

Indian journal of medical sciences·2005
Same author

Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means.

Journal of neuroendocrinology·2005
Same author

Personalised image-based templates for intra-operative guidance.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2005
Same author

Impact of heart failure on quality of sleep.

Postgraduate medical journal·2005
Same author

Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe.

Journal of neuroendocrinology·2005
Same author

Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis.

Molecular genetics and genomics : MGG·2005

For stage IA/IAE large cell lymphoma, radiation therapy alone shows similar survival and recurrence rates compared to combined modality therapy (CMT). This study suggests radiation alone may be sufficient, reserving chemotherapy for treatment failure.

Area of Science:

  • Oncology
  • Hematology
  • Clinical Research

Background:

  • Large cell lymphoma is a significant hematologic malignancy.
  • Treatment strategies for early-stage disease are continually evaluated.
  • Combined modality therapy (CMT) is often recommended for large cell lymphoma.

Purpose of the Study:

  • To evaluate and compare treatment outcomes for stage IA/IAE large cell lymphoma.
  • To determine if radiation therapy alone is as effective as CMT.
  • To analyze survival curves and recurrence patterns based on treatment modality.

Main Methods:

  • Retrospective review of 52 patients with stage IA/IAE large cell lymphoma.
  • Pathology slides reviewed by a single, specialized pathologist.
  • Patients categorized into two groups: radiation alone (26 patients) and CMT (26 patients).

Related Experiment Videos

Main Results:

  • No statistically significant difference in survival curves between radiation alone and CMT groups (p > 0.05).
  • Similar recurrence patterns observed for both treatment modalities.
  • The study identified no superior outcomes with CMT in this patient cohort.

Conclusions:

  • Radiation therapy alone appears to be a viable treatment option for stage IA/IAE large cell lymphoma.
  • CMT does not demonstrate superior survival or recurrence control compared to radiation alone in this study.
  • Chemotherapy can be reserved as a secondary treatment for cases that fail initial radiation therapy.