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Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney

K Yoshioka1, T Takemura, M Kanasaki

  • 1Department of Paediatrics, Kinki University School of Medicine, Osaka-sayama, Japan.

Pediatric Nephrology (Berlin, Germany)
|March 1, 1991
PubMed

Infiltrating cells were analysed in renal biopsy tissue obtained from a 15-year-old girl with acute interstitial nephritis and uveitis using monoclonal antibodies specific for mononuclear cell surface markers. The interstitial infiltrates consisted mainly of T cells and monocytes/macrophages. A considerable proportion of the infiltrating cells were identified by a monoclonal antibody against the interleukin-2 receptor, indicating that a majority of those immune cells are activated. This observation documents the participation of cell-mediated immune injury in interstitial nephritis associated with uveitis.

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