Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene regulation by interleukin 6.

G H Fey1, M Hattori, G Hocke

  • 1Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Biochimie
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of mHealth interventions targeting physical activity, sedentary behaviour, sleep or nutrition on emotional, behavioural and eating disorders in adolescents: a systematic review and meta-analysis.

Frontiers in digital health·2025
Same author

[Central neurological complication of an interscalene plexus catheter].

Der Anaesthesist·2021
Same author

Acidification and hypoxia interactively affect metabolism in embryos, but not larvae, of the coastal forage fish <i>Menidia menidia</i>.

The Journal of experimental biology·2020
Same author

Thia-analogues of amino acids synthesis of peptide derivatives containing 3-thia-analogues of amino acids.

Amino acids·2013
Same author

Interleukin-1α is the major alarmin of lung epithelial cells released during photodynamic therapy to induce inflammatory mediators in fibroblasts.

British journal of cancer·2012
Same author

The association of statins and taxanes: an efficient combination trigger of cancer cell apoptosis.

British journal of cancer·2012

Interleukin 6 (IL-6) signaling involves common nuclear factors binding to response elements in liver and B cells. The conserved IL-6 receptor structure suggests downstream signaling, not receptor differences, dictates cell-specific responses.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Signaling

Background:

  • Interleukin 6 (IL-6) is a key hormone regulating inflammation, immune responses, and cell growth.
  • The precise IL-6 signal transduction pathway remains incompletely understood.
  • IL-6 influences diverse cellular processes, including acute phase protein synthesis in the liver and proliferation of myeloma cells.

Purpose of the Study:

  • To elucidate the molecular mechanisms of IL-6 signal transduction.
  • To identify and characterize nuclear factors involved in IL-6-mediated gene transcription.
  • To investigate the role of the IL-6 receptor in mediating cellular responses.

Main Methods:

  • Mapping of an IL-6-response element (IL-6-RE) in the 5' flanking region of the alpha 2-macroglobulin gene.

Related Experiment Videos

  • Characterization of nuclear factors binding to the IL-6-RE in hepatic cells and human B cells.
  • Cloning and sequencing of the rat liver IL-6 receptor (IL-6-R).

    • Main Results:

    • An IL-6-RE (CTGGGA) was identified, serving as a binding site for IL-6-modulated nuclear factors.
    • Similar IL-6-induced nuclear factors were found in rat liver cells and human B cells, binding to the IL-6-RE.
    • The rat liver IL-6-R shares significant sequence identity (53%) with the human leukocyte IL-6-R, with conserved functional domains.

    Conclusions:

    • Common molecular elements likely mediate IL-6 signal transduction in both liver and B cells.
    • The conserved structure of the IL-6 receptor suggests that cell-type specific responses are determined by downstream signaling components, not receptor variants.