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Near-infrared spectroscopy in peripheral vascular disease
T R Cheatle1, L A Potter, M Cope
1Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London, UK.
The British Journal of Surgery
|April 1, 1991
Summary
Near-infrared spectroscopy reveals reduced calf muscle oxygen consumption in peripheral vascular disease patients compared to healthy controls. This non-invasive technique aids in assessing treatment effectiveness for vascular conditions.
Area of Science:
- Biomedical Engineering
- Physiology
- Vascular Medicine
Background:
- Peripheral vascular disease (PVD) impairs blood flow to the limbs, affecting muscle metabolism.
- Assessing muscle oxygenation and consumption is crucial for diagnosing and managing PVD.
Purpose of the Study:
- To investigate calf muscle oxygen consumption and reoxygenation dynamics in patients with PVD.
- To evaluate the utility of near-infrared spectroscopy (NIRS) as a non-invasive tool for PVD assessment.
Main Methods:
- Near-infrared spectroscopy (NIRS) was employed to monitor oxyhaemoglobin and deoxyhaemoglobin changes in calf muscles.
- 38 subjects (21 controls, 17 PVD patients) underwent NIRS during tourniquet-induced ischemia and subsequent reoxygenation.
Main Results:
- Patients with PVD exhibited significantly lower median oxygen consumption (0.10 ml/100g/min) compared to controls (0.20 ml/100g/min).
- The time to reach maximum oxyhaemoglobin levels post-ischemia was longer in PVD patients (40s) than in controls (20s).
Conclusions:
- NIRS demonstrates reduced muscle oxygen consumption in individuals with peripheral vascular disease.
- This non-invasive method shows promise for monitoring metabolic improvements in response to PVD treatments.