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Herpes simplex virus types 1 and 2 in ocular disease
Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 1, 1978
Summary
Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) cause herpetic eye disease. Strain differences in HSV-1 correlate with clinical outcomes, suggesting further virologic study is needed.
Area of Science:
- Ophthalmology
- Virology
- Infectious Diseases
Background:
- Herpetic eye disease is a significant cause of visual impairment.
- Herpes simplex virus (HSV) is the primary viral agent implicated in herpetic eye disease.
- Understanding the specific types and strains of HSV involved is crucial for effective management.
Observation:
- A study of 457 patients with presumed herpetic eye disease identified 154 cases of HSV-1 and 3 cases of HSV-2.
- Detailed analysis of 219 viral isolates revealed significant strain variations within HSV types.
- Clinical presentations of the three HSV-2 infections were documented.
Findings:
- HSV-1 was the predominant type identified in herpetic eye disease cases.
- Substantial strain differences were observed in HSV isolates, beyond type-specific characteristics.
- A potential correlation between clinical course and HSV-1 growth characteristics was noted.
Implications:
- Further virologic differentiation of HSV-1 strains may be beneficial for understanding disease progression.
- Distinguishing between HSV types and strains could lead to more targeted therapeutic strategies.
- This research contributes to the understanding of viral factors influencing herpetic eye disease severity.