Related Experiment Video
Updated: Jun 14, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Eccrine Function in Psoriasis Inversus
Abstract:
Seven patients with psoriatic lesions of axilla and internatal cleft were tested by thermal and intradermal methacholine stimulation using the quinizarin test for sweating to determine the source of moisture causing maceration and absence of scaling in psoriasis inversus.Histopathological changes were non-specific: slight and patchy hyperkeratosis and parakeratosis, slight elongation of rete ridges and thinning of suprapapillary plates, microspongiosis and vesiculation in variably acanthotic prickle cell layer; dilated capillary loops less prominent than in typical psoriasis.Lesions clinically and histopathologically consistent with psoriasis inversus were anhidrotic. Maceration was due to spread of sweat from adjacent uninvolved skin, spongiosis and vesiculation, serum exudation and insensible perspiration.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Clinical Applications of Epidermal Stem Cells
Accessory Structures of the Skin: Sebaceous Glands
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Renewal of Skin Epidermal Stem Cells
Introduction to the Integumentary System
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...