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Related Experiment Video

Updated: Jun 14, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Eccrine Function in Psoriasis Inversus.

J C Mitchell, J Forstner

Canadian Medical Association Journal

|March 24, 2010

Summary

This summary is machine-generated.

Psoriasis inversus lesions in the axilla and internatal cleft were found to be anhidrotic (lacking sweat glands). Maceration in these psoriatic lesions results from adjacent sweat spread, not intrinsic sweating.

Related Experiment Videos

Last Updated: Jun 14, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Clinical Investigation

Background:

Psoriasis inversus presents unique challenges in intertriginous areas.
Maceration and absence of scaling are characteristic clinical features.

Purpose of the Study:

To investigate the sweating response in patients with psoriasis inversus.
To determine the source of moisture contributing to maceration in these lesions.

Main Methods:

Utilized the quinizarin test for sweating assessment.
Administered thermal and intradermal methacholine stimulation.
Performed histopathological examination of psoriatic lesions.

Main Results:

Psoriatic lesions in the axilla and internatal cleft were clinically and histopathologically consistent with psoriasis inversus.
These lesions were found to be anhidrotic, lacking a sweating response.
Histopathology revealed non-specific changes, with less prominent dilated capillary loops than typical psoriasis.

Conclusions:

The maceration observed in psoriasis inversus is not caused by intrinsic sweating within the lesions.
Moisture originates from the spread of sweat from adjacent unaffected skin, alongside serum exudation and insensible perspiration.