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Related Experiment Videos

Anti-plaque dentifrices: current status and prospects.

F van der Ouderaa1, D Cummins

  • 1Unilever Dental Research, Port Sunlight Laboratory, Bebington, UK.

International Dental Journal
|April 1, 1991
PubMed
Summary

Dentifrices can effectively deliver anti-plaque agents if they are bioavailable and retained in the mouth. Compatible agents in toothpaste show promising results for reducing plaque and gingivitis.

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Area of Science:

  • Oral hygiene
  • Dental pharmacology
  • Drug delivery systems

Background:

  • Dentifrices are potential delivery vehicles for anti-plaque agents.
  • Agent bioavailability and retention (substantivity) are crucial for efficacy.
  • Compatibility of anti-plaque agents with dentifrice formulations is essential for release and retention.

Purpose of the Study:

  • To evaluate the potential of dentifrices as delivery vehicles for anti-plaque agents.
  • To highlight the importance of agent bioavailability and substantivity.
  • To discuss compatible anti-plaque agents for dentifrice formulations.

Main Methods:

  • Review of existing literature on anti-plaque agents and dentifrice formulations.
  • Analysis of studies investigating agent release and retention from dentifrices.
  • Examination of clinical data on anti-plaque and anti-gingivitis efficacy.

Main Results:

  • Dentifrices can be effective delivery systems for anti-plaque agents.
  • Successful delivery requires agent bioavailability and oral retention.
  • Compatible agents, including metal ions and non-charged phenolic agents, show promise.
  • Long-term studies demonstrate favorable anti-plaque and anti-gingivitis activity.

Conclusions:

  • Optimized dentifrice formulations can successfully deliver anti-plaque agents.
  • Agent substantivity is key for sustained therapeutic effects.
  • Further research into compatible agents can enhance oral hygiene outcomes.

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