Related Experiment Video
Updated: Jun 14, 2026
05:11
Treatment of Middle-segment Pancreatic Benign Tumor Using Laparoscopic Central Pancreatectomy with End-to-end Pancreatic Duct Reconstruction
Published on: January 2, 2026
The pancreozymin-secretin test after partial gastrectomy.
Canadian Medical Association Journal
|March 24, 2010
Summary
Pancreozymin and secretin stimulation did not elevate serum amylase in patients after partial gastrectomy. Basal serum lipase levels were sometimes high, but rarely increased with stimulation, limiting diagnostic utility.
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Partial gastrectomy alters digestive anatomy and function.
- Assessing pancreatic exocrine function post-gastrectomy is clinically relevant.
Purpose of the Study:
- To evaluate the response of serum amylase and lipase to pancreozymin and secretin stimulation in post-gastrectomy patients.
- To assess the diagnostic utility of duodenal aspirates for pancreatic function tests after partial gastrectomy.
Main Methods:
- Administered pancreozymin and secretin to control and post-gastrectomy patients.
- Measured serum amylase and lipase levels pre- and post-stimulation.
- Collected and analyzed duodenal aspirates for volume, bicarbonate, and amylase content.
Main Results:
- No significant increase in serum amylase was observed after stimulation in any group.
- Elevated basal serum lipase was noted in some post-gastrectomy patients, with minimal increase upon stimulation.
- Duodenal aspirate analysis showed high variability in volume, bicarbonate, and amylase, limiting diagnostic interpretation.
Conclusions:
- Serum amylase and lipase stimulation tests have limited diagnostic value in patients following partial gastrectomy.
- Variability in duodenal aspirate composition complicates the assessment of pancreatic exocrine function.
Related Concept Videos
01:26Pancreatic Juice and Secretion
Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
01:27Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
Insulin and C-peptide are co-secreted in...
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...