Clinical characteristics of spinal involvement in hepatocellular carcinoma

To analyze the clinical characteristics of hepatocellular carcinoma (HCC) with spinal metastasis.

During a period of 14 years, 42 HCC patients with cranial and/or spinal metastasis were identified. Among them, 12 had spinal involvement and thus were included for study. The clinical, laboratory and neuroimaging data of these 12 cases were analyzed.

The 12 cases were all male, aged 36-65 years. The time interval from the diagnosis of HCC to the finding of spinal involvement was 0-38 months. Among these 12 cases, four had the features of spinal involvement in the initial presentation of their HCC. Low back pain was the most common symptom followed by weakness and numbness in the lower limbs. A serum biochemical study did not show unique findings. All 12 cases died within nine months after the diagnosis of the HCC spinal involvement.

28.6% (12/42) of the HCC patients with nervous system metastasis had spinal involvement and the exact incidence rate can be increased by more extensive neuroimaging studies. Viral hepatitis and liver cirrhosis are common preceding events in patients with HCC with spinal involvement. T- and L-spine are the most commonly involved segments and back pain is the most common complaint in patients with HCC with spinal metastasis. The prognosis in this group of patients is grave and most of the patients died soon after the development the HCC's spinal involvement. No specific biomarker can predict the development of spinal involvement in HCC patients and diagnostic consideration can only be emphasized, especially in HCC hyperendemic areas such as Taiwan.