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Dynamic cyclic thiodepsipeptide libraries from thiol-thioester exchange
Soumyadip Ghosh1, Lindsey A Ingerman, Aaron G Frye
1Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Organic Letters
|March 25, 2010
Abstract:
Thiol-thioester exchange was found to readily generate libraries of cyclic thiodepsipeptides under thermodynamic control, which will enable their use in a variety of dynamic combinatorial chemistry assays. The kinetic determinants of macrocycle formation and the role of amino acid structure on the reaction dynamics are discussed.
