Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutagens in human breast cyst fluid.

W N Scott1, W R Miller

  • 1University Department of Surgery, Royal Infirmary, Edinburgh, UK.

Journal of Cancer Research and Clinical Oncology
|January 1, 1991
PubMed
Summary

Breast cyst fluids from 439 women were tested for mutagenic activity using the Ames test. Nearly 10% of samples showed mutagen-positive results, with no clear link to patient data, suggesting diverse chemical agents may be involved.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The new Knee Society Knee Scoring System.

Clinical orthopaedics and related research·2011
Same author

Growth-control of human ovarian-carcinoma cells by insulin-like growth-factors.

Oncology reports·2011
Same author

Safety issues surrounding the use of aromatase inhibitors in breast cancer.

Expert opinion on drug safety·2003
Same author

Pathological features of breast cancer response following neoadjuvant treatment with either letrozole or tamoxifen.

European journal of cancer (Oxford, England : 1990)·2003
Same author

Aromatase in skeletal muscle.

The Journal of steroid biochemistry and molecular biology·2003
Same author

The therapeutic potential of aromatase inhibitors.

Expert opinion on investigational drugs·2003

Area of Science:

  • Biochemistry
  • Oncology
  • Toxicology

Background:

  • Palpable breast cysts are common in women.
  • Mutagenic activity in biological fluids may indicate potential health risks.

Purpose of the Study:

  • To investigate the presence and characteristics of mutagenic activity in breast cyst fluids.
  • To determine if mutagenicity correlates with clinical or epidemiological factors.

Main Methods:

  • Aspiration of cyst fluids from patients with palpable breast cysts.
  • Analysis of mutagenic activity using the Ames test.
  • Preliminary chemical characterization of identified mutagens.

Main Results:

  • Mutagenic activity was detected in 9.6% of the 439 breast cyst fluid samples analyzed.
  • No significant correlation was found between mutagen-positive fluids and patient clinical or epidemiological data.
  • Initial characterization indicated that the mutagenic agents possess varied chemical properties.

Conclusions:

  • A notable proportion of breast cyst fluids exhibit mutagenic potential.
  • The presence of mutagens in breast cyst fluid does not appear to be linked to readily available patient information.
  • Further research is needed to identify the specific chemical agents responsible for the observed mutagenicity.

Related Experiment Videos