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Regulators of the cohesin network
1Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA. bxi@stowers.org
Annual Review of Biochemistry
|March 25, 2010
Summary
Chromosome cohesion ensures sister chromatids separate correctly during cell division. This review explores how regulatory networks and modifications control cohesion for DNA repair and gene regulation.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Chromosome cohesion is vital for holding sister chromatids together from replication until anaphase.
- It is essential for accurate chromosome segregation during cell division.
- Cohesion also plays roles in DNA double-strand break (DSB) repair and gene transcriptional regulation.
Purpose of the Study:
- To review recent advancements in understanding the regulation of the chromosome cohesion network.
- To highlight the differential regulation of cohesion in various cellular contexts.
- To focus on regulation through effectors and posttranslational modifications.
Main Methods:
- Literature review of recent developments in chromosome cohesion research.
- Analysis of regulatory mechanisms involving effectors.
- Examination of posttranslational modifications impacting cohesion.
Main Results:
- The chromosome cohesion network, while shared, is differentially regulated for distinct functions like segregation, DSB repair, and gene regulation.
- Effectors and posttranslational modifications are key regulatory mechanisms.
- Complex regulatory networks enable context-specific control of cohesion.
Conclusions:
- The regulation of chromosome cohesion is multifaceted, involving intricate networks.
- Differential regulation allows cohesion to serve diverse roles within the cell.
- Emerging research reveals complex control mechanisms governing DNA sequence interactions.
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