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Updated: Jun 14, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy
Serhiy Havrylov1, Maria Jolanta Redowicz, Vladimir L Buchman
1Nencki Institute of Experimental Biology, Pasteura 3 Street, 02-093 Warsaw, Poland.
Abstract:
Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.
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