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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 14, 2026

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

A quantitative proteomic analysis of long-term memory.

David Rosenegger¹, Cynthia Wright, Ken Lukowiak

¹Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

Molecular Brain

|March 25, 2010

Summary

This summary is machine-generated.

Researchers identified novel proteins crucial for long-term memory (LTM) formation using quantitative proteomics. This study reveals new molecular players involved in memory persistence and provides candidates for future research.

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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Related Experiment Videos

Last Updated: Jun 14, 2026

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Area of Science:

Neuroscience
Molecular Biology
Proteomics

Background:

Long-term memory (LTM) involves storing, retaining, and retrieving information.
LTM formation requires DNA transcription, RNA translation, and protein synthesis.
The complexity of memory formation suggests many proteins remain undiscovered.

Purpose of the Study:

To identify novel proteins associated with long-term memory formation.
To investigate the proteomic changes in neural tissue during LTM acquisition.

Main Methods:

Quantitative proteomic analysis of neural tissue.
In vivo training of animals to form long-term memories.
Comparison of protein expression between trained and control groups.

Main Results:

Identified 8 significantly up-regulated and 13 down-regulated proteins in LTM-trained animals.
Discovered 19 proteins unique to trained animals and 12 unique to control animals.
Confirmed involvement of known memory proteins like protein kinase C (PKC), adenylate cyclase (AC), and mitogen-activated protein kinase (MAPK) pathway proteins.

Conclusions:

The study validates known proteins involved in memory.
Novel protein candidates, such as UHRF1 binding protein, were identified for future research.
These findings advance our understanding of the molecular mechanisms underlying memory persistence.