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Updated: Jun 14, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Cognitive-behavioral therapy for patients with Parkinson's disease and comorbid major depressive disorder
Amy Farabaugh1, Joseph J Locascio, Liang Yap
1Depression Clinical & Research Program, Department of Neurology, Massachusetts General Hospital, 15 Parkman St., Wac 812, Boston, MA 02114, USA. afarabaugh@partners.org
Background:
Depression has been recognized as a common feature of Parkinson's disease (PD), and is the most prevalent psychiatric disorder in PD patients.
Objective:
The authors sought to determine whether cognitive-behavioral therapy (CBT) is effective in the treatment of depression within the context of PD (dPD).
Method:
The authors enrolled 8 depressed PD patients into an open treatment study of 12 weeks of individual CBT treatment.
Results:
There was a significant linear decrease in mean Hamilton Rating Scale for Depression (17-item) scores over Weeks 0 to 12, and 57% of patients (4/7) met criteria for remission at endpoint.
Conclusion:
This uncontrolled study suggests that CBT may be effective in treating dPD and may be an alternative or adjunct to pharmacological treatment.
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