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Updated: Jun 14, 2026

Quality-Controlled Sputum Analysis by Flow Cytometry
Published on: August 9, 2021
Interphase cytogenetics of sputum cells for the early detection of lung carcinogenesis
Sheila A Prindiville1, Thomas Ried
1Coordinating Center for Clinical Trials, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852-4910, USA. sheila.prindiville@nih.gov
Abstract:
This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) examines the role of interphase fluorescence in situ hybridization for the early detection of lung cancer. This work is an important step toward identifying and validating a molecular marker in sputum samples for lung cancer early detection and highlights the value of establishing cohort studies with biorepositories of samples collected from participants followed over time for disease development.
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