Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diurnal changes in the stomatal, mesophyll, and biochemical limitations of photosynthesis in well-watered greenhouse-grown strawberries.

Photosynthetica·2024
Same author

HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development.

Journal of dental research·2022
Same author

Talbot interferometry for imaging two-dimensional electron density distribution over discharge plasma with higher sensitivity.

The Review of scientific instruments·2019
Same author

Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model.

Journal of dental research·2018
Same author

Long-term use of an ultrapotent topical steroid for the treatment of vulval lichen sclerosus is safe.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2015
Same author

Identification and characterization of novel Staphylococcus aureus pathogenicity islands encoding staphylococcal enterotoxins originating from staphylococcal food poisoning isolates.

Journal of applied microbiology·2015

Related Experiment Video

Updated: Jun 14, 2026

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
07:39

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay

Published on: July 26, 2022

Differences between orofacial inflammation and cancer pain.

N Harano1, K Ono, K Hidaka

  • 1Department of Control of Physical Functions, Kyushu Dental College, 2-6-1 Manazuru, Kokurakitaku, Kitakyushu, Fukuoka, 803-8580, Japan.

Journal of Dental Research
|March 25, 2010
PubMed
Summary

Orofacial cancer pain in rats is not primarily driven by inflammation. Anti-inflammatory drugs showed limited effects on cancer pain, unlike in inflammation models, suggesting distinct pain mechanisms.

More Related Videos

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
06:37

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
09:05

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

Related Experiment Videos

Last Updated: Jun 14, 2026

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
07:39

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay

Published on: July 26, 2022

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
06:37

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
09:05

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

Area of Science:

  • Neuroscience
  • Oncology
  • Pain Research

Background:

  • Orofacial cancer in rat models causes pain, including allodynia and hyperalgesia.
  • The role of inflammation in cancer-induced orofacial pain remains unclear.

Purpose of the Study:

  • To investigate whether cancer-induced orofacial pain is secondary to inflammation.
  • To compare the effects of indomethacin on pain and neurochemical changes in orofacial inflammation and cancer models.

Main Methods:

  • Utilized rat models of orofacial inflammation and cancer.
  • Administered indomethacin peripherally to assess its impact on pain behaviors.
  • Analyzed neurochemical changes, specifically calcitonin gene-related peptide and substance P, in the medullary dorsal horn.

Main Results:

  • Indomethacin significantly suppressed pain in the inflammation model.
  • Indomethacin showed only weak suppression of pain in the cancer model.
  • Medullary dorsal horn levels of calcitonin gene-related peptide and substance P increased in inflammation but not in cancer.

Conclusions:

  • Orofacial cancer pain in rats is not significantly mediated by peripheral inflammation.
  • While inflammation may play a minor role, distinct mechanisms likely drive cancer-induced orofacial pain.