Related Experiment Video

Updated: Jun 14, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Prevalence and management of non-albicans vaginal candidiasis

Nalin Hettiarachchi1, Nalin Hetticarachchi, H Ruth Ashbee

  • 1Department of Genitourinary Medicine, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.

Sexually Transmitted Infections
|March 25, 2010
PubMed
Abstract

Insights

Non-albicans Candida species, like Candida glabrata, remain stable in prevalence. Amphotericin and flucytosine vaginal cream effectively treated non-albicans vulvovaginal candidiasis (VVC) in 18 women.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Widespread azole use may increase resistant Candida species, including Candida glabrata.
  • Infections with non-albicans Candida species often resist standard azole treatments.
  • Intravaginal nystatin is no longer available in the UK.

Purpose of the Study:

  • To review the prevalence of non-albicans Candida over five years.
  • To assess the efficacy of amphotericin and flucytosine vaginal cream for non-albicans VVC.

Main Methods:

  • Retrospective review of vaginal yeast isolates from 2004-2008.
  • Identification of patients prescribed amphotericin and flucytosine vaginal cream.
  • Review of clinical notes for treatment outcomes.

Main Results:

  • Non-albicans yeast prevalence remained stable (0.87-1.06%) between 2004-2008.
  • All 18 patients treated with amphotericin and flucytosine cream cleared their initial yeast isolate.
  • Two patients experienced persistent symptoms and positive Candida albicans cultures.

Conclusions:

  • No evidence of increased prevalence for non-albicans Candida species like C. glabrata.
  • Amphotericin and flucytosine vaginal cream achieved clearance of non-albicans species in all treated patients.

More Related Videos

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis07:57

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...