Paraoxonase activity in athletic adolescents
Alpay Cakmak1, Dost Zeyrek, Ali Atas
1Dept. of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
Pediatric Exercise Science
|March 25, 2010
Summary
Adolescent athletes show higher paraoxonase activity, an enzyme linked to cardiovascular protection. Regular physical activity may enhance this protective effect against heart disease.
Area of Science:
- Cardiovascular Health
- Exercise Physiology
- Biochemistry
Background:
- Regular physical activity is associated with reduced cardiovascular disease risk in adults.
- Paraoxonase activity is hypothesized to mediate the cardio-protective effects of exercise.
Purpose of the Study:
- To compare paraoxonase activity and other antioxidative markers in adolescent athletes versus inactive youth.
- To investigate the role of paraoxonase in exercise-induced cardio-protection during adolescence.
Main Methods:
- Comparative analysis of paraoxonase levels in adolescent athletes and a control group of inactive youth.
- Measurement of total antioxidative capacity, total oxidative status, oxidative stress index, and lipid hydroperoxide.
- Statistical comparison of biochemical markers between the two groups.
Main Results:
- Adolescent athletes exhibited significantly higher paraoxonase levels (177.32 U/L) compared to inactive controls (98.11 U/L) (P < 0.0001).
- Markers of oxidative stress, including total antioxidative capacity, total oxidative status, oxidative stress index, and lipid hydroperoxide, were significantly elevated in athletes (P < 0.0001).
Conclusions:
- Adolescent athletes demonstrate enhanced paraoxonase activity compared to their inactive peers.
- Increased paraoxonase activity in athletes suggests a potential mechanism for the cardio-protective benefits of regular physical activity.
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