[A case of malignant pleural mesothelioma that responded to cisplatin plus pemetrexed rechallenge]

We present a case of malignant pleural mesothelioma which responded to a cisplatin plus pemetrexed rechallenge. A 78- year-old man was diagnosed as stage IV malignant pleural mesothelioma in International Mesothelioma Interest Group (IMIG) stage by biopsy using ultrasonography and chest to abdominal CT. 6 courses of cisplatin at 60 mg/m2 plus pemetrexed at 500 mg/m2 were administered every 3 to 4 weeks. After this treatment, all of the lesions shrank, and the best overall response was partial response (PR) in Response Evaluation Criteria in Solid Tumors (RECIST). Although vinorelbine, gemcitabine and S-1 were administered subsequently because of the re-growth of the lesions, they were enlarged. Cisplatin plus pemetrexed was administered as fifth-line chemotherapy again, the lesions shrank, and the best overall response was PR in RECIST.