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Related Experiment Videos

Comparative study between different schedules for sclerosing oesophageal varices.

M M Massoud1, E Saleh, S M Massoud

  • 1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Journal of the Egyptian Society of Parasitology
|April 1, 1991
PubMed
Summary

A one-week interval for sclerotherapy sessions showed no difference in complications or sclerosant volume compared to two weeks. However, the two-week interval achieved earlier eradication of varices.

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Area of Science:

  • Gastroenterology
  • Endoscopic procedures
  • Vascular interventions

Background:

  • Esophageal varices pose a significant bleeding risk in patients with portal hypertension.
  • Sclerotherapy is a common endoscopic treatment for esophageal varices.
  • Optimizing the interval between sclerotherapy sessions is crucial for effective treatment and patient outcomes.

Purpose of the Study:

  • To compare the efficacy and safety of one-week versus two-week intervals for esophageal variceal sclerotherapy.
  • To evaluate differences in treatment duration, sclerosant volume, and complication rates between the two interval groups.

Main Methods:

  • A comparative study involving two groups of patients undergoing sclerotherapy for esophageal varices.
  • One group received sclerotherapy at one-week intervals, while the other received it at two-week intervals.

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  • Data collected included total sessions, sclerosant volume (5% ethanolamine oleate), complication rates, and time to variceal eradication.

    • Main Results:

    • No significant differences were observed in the total number of sclerotherapy sessions, total sclerosant volume, or complication rates (pyrexia, stricture ulcer, slough formation) between the one-week and two-week interval groups.
    • No early or recurrent bleeding events occurred in either group.
    • Variceal eradication was achieved significantly earlier in the two-week interval group compared to the one-week interval group (P < 0.05).

    Conclusions:

    • A two-week interval for sclerotherapy may lead to more rapid eradication of esophageal varices compared to a one-week interval.
    • Both one-week and two-week intervals appear to be safe and equally effective in terms of total sessions, sclerosant volume, and complication rates.