Pathological and immunopathological changes in albino mice experimentally infected with Hymenolepis nana

The pathological and immunopathological effects of H. nana on experimentally infected albino mice were studied, sacrificed one, three and five months post egg inoculation. The results showed that most of the mice had diarrhoea, loss of appetite and were inactive. On the other hand, the liver and spleen showed some pathological changes and cysticercoids were seen particularly in the liver. The kidneys showed cloudy swelling (3/90). The brain showed oedema (15/90) and glyosis (15/90). Intestinal atrophy and ulceration were very marked (30/90) with negative reaction to PAS and Alcian blue stain. Cysticercoids were seen in intestinal villi. The immunoglobulins in sections of the S. intestine changed from moderate to negative (IgA) or to mild (IgM) or from mild to marked (IgG). The whole results were discussed.