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Triggering of dendritic cell apoptosis by xanthohumol

Nguyen Thi Xuan1, Ekaterina Shumilina, Erich Gulbins

  • 1Department of Physiology, University of Tübingen, Tübingen, Germany.

Molecular Nutrition & Food Research
|March 25, 2010
PubMed
Summary

Xanthohumol, a beer flavonoid, triggers apoptosis in immune cells by activating acid sphingomyelinase (Asm). This leads to ceramide formation, caspase activation, and programmed cell death in dendritic cells.

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