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Related Concept Videos

Scientific Nature of Social Psychology01:30

Scientific Nature of Social Psychology

Social psychology is a scientific discipline dedicated to understanding how individuals think, feel, and behave in social contexts. Unlike common sense, which relies on anecdotal experiences and intuition, social psychology employs systematic research and empirical methods to ensure objectivity and reliability. This distinction is fundamental in distinguishing scientifically supported findings from mere speculation.Four fundamental scientific values guide a structured approach to research in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Defining Social Psychology01:09

Defining Social Psychology

Social psychology investigates how the presence and actions of others influence individual behavior, cognition, and emotion. Examining the social environment's impact provides a scientific framework for understanding how individuals perceive others and are, in turn, influenced by them. This field seeks to uncover the underlying principles guiding social interactions, exploring phenomena such as conformity, obedience, and prosocial behavior.Core Themes in Social PsychologyOne central focus of...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

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Related Experiment Video

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Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
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Published on: February 25, 2011

Disentangling the translational sciences: a social science perspective.

Louis D Burgio1

  • 1University of Michigan, School of Social Work, Institute of Gerontology, Ann Arbor 48109-1106, USA. lburgio@umich.edu

Research and Theory for Nursing Practice
|March 26, 2010
PubMed
Summary

Translational science faces challenges in moving interventions from clinical trials to communities. This article explores four strategies to improve intervention dissemination and calls for a unified interdisciplinary approach.

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Area of Science:

  • Social Science
  • Translational Science

Background:

  • Translational science is a nascent field with interdisciplinary approaches.
  • Discrepancies exist in terminology, definitions, and conceptualization of clinical research stages.

Purpose of the Study:

  • To examine translational science from a social science perspective.
  • To identify challenges and strategies for moving interventions from clinical trials to community settings.

Main Methods:

  • Review of literature on translational science and social science perspectives.
  • Discussion of four proposed strategies for intervention translation: health services research methods, data-driven modification criteria, community-based participatory action research (CBPR), and a hybrid system.

Main Results:

  • Significant challenges exist in disseminating clinical trial interventions to the community.
  • Four distinct strategies are proposed to facilitate the translation of interventions.

Conclusions:

  • Translational science in social sciences is at a critical juncture, with intervention dissemination as a key challenge.
  • A unified, interdisciplinary science of translation is essential for progress, despite existing barriers.