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Hemorheology, stroke and the elderly.

O Elwan1, S al-Ashmawy, S el-Karaksy

  • 1Neurology Department, Faculty of Medicine, Cairo University, Egypt.

Journal of the Neurological Sciences
|February 1, 1991
PubMed
Summary

Whole blood filterability, a measure of blood flow, is reduced in stroke patients, particularly the elderly. This decline is linked to red blood cell deformability and plasma factors, impacting hemorheologic parameters.

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Area of Science:

  • Gerontology
  • Hemorheology
  • Vascular Medicine

Background:

  • Stroke is a significant health concern, especially in the elderly.
  • Hemorheologic parameters, including blood filterability, play a crucial role in microcirculation and stroke pathophysiology.
  • Age-related changes can exacerbate hemorheologic alterations.

Purpose of the Study:

  • To investigate whole blood filterability in stroke patients, focusing on age-related differences.
  • To identify hemorheologic factors contributing to reduced blood filterability in stroke patients.
  • To assess the impact of aging on blood filterability in the context of stroke.

Main Methods:

  • Whole blood filterability was assessed in 53 stroke patients (28 aged 40-60 years, 25 >60 years).

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  • Correlations were analyzed between filterability and hematocrit, plasma viscosity, and macroprotein levels (alpha 2-globulin, gamma-globulin, fibrinogen).
  • Comparisons were made between stroke patients and normal controls, and between younger and older stroke patient groups.

    • Main Results:

    • Whole blood filterability showed a negative linear correlation with hematocrit, plasma viscosity, and macroprotein levels.
    • Stroke patients exhibited significantly reduced whole blood filterability compared to controls.
    • The reduction in filterability was primarily attributed to decreased red blood cell deformability, not hematocrit or plasma viscosity.
    • Blood filterability was significantly lower in stroke patients over 60 years old compared to those under 60.
    • Both plasma and red blood cell factors contributed to reduced filterability in elderly stroke patients.

    Conclusions:

    • Whole blood filterability is a comprehensive indicator of hemorheologic status in stroke patients.
    • Reduced red blood cell deformability is a key factor in impaired blood filterability post-stroke.
    • Aging significantly worsens blood filterability in stroke patients due to combined plasma and red cell changes.
    • These findings highlight the importance of addressing hemorheologic alterations, particularly in elderly stroke survivors.