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Updated: Jun 14, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
Published on: March 12, 2019
Fetal and newborn adrenocortical tumors
1Department of Pathology, Rady Children's Hospital San Diego, CA 92123, USA. hisaacs@ucsd.edu
Abstract:
Adrenocortical tumors occur less often in the fetus and newborn than later in life. The purpose of this study was to focus on the fetus and newborn in an attempt to determine the various ways these tumors differ in their biologic behavior, pathology, clinical presentation and response to therapy from those occurring in the older child and adolescent. Twenty-five fetuses and newborns were diagnosed with ACTs prenatally (n = 3) and in the newborn period (n = 22). The study consisted of two main neoplasms: adrenocortical adenoma, 24%, and adrenocortical carcinoma, 76%. The most common presenting finding was an abdominal mass. Overall survival for patients with ACA and ACC were 33% and 53%, respectively.
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