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T cell tolerance towards the fetal allograft

Marie-Pierre Piccinni1

  • 1Center of Excellence for Research, Transfer and High Education DENOTHE of the University of Florence, Florence, Italy. mppiccinni@hotmail.com

Journal of Reproductive Immunology
|March 26, 2010
PubMed

The conceptus is considered a semi-allograft because of the presence of paternal HLA-C molecules. These alloantigens can be processed by maternal antigen presenting cells, which present them to specific maternal CD4+ T cells. After activation, the maternal CD4+ T cells can become effector decidual CD4+ T cells, which are able to release various cytokines. Th1-type cytokines (IFNgamma) that promote allograft rejection may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-10) that inhibit Th1 responses, promote allograft tolerance and therefore may improve fetal survival. A collaborative interaction between the decidual natural regulatory T cells, CD4+ CD25+ Foxp3 T cells and NKT cells in preventing fetal allograft rejection is suggested.

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