Gender differences in delusional disorder: Evidence from an outpatient sample

Area of Science:

• Psychiatry
• Clinical Psychology
• Neuroscience

Background:

• Delusional disorder (DD) is a psychiatric condition characterized by persistent delusions.
• Understanding gender differences in DD is crucial for tailored treatment strategies.
• Previous research has not comprehensively examined gender-specific risk factors, clinical features, and functional outcomes in DD.

Purpose of the Study:

• To investigate gender disparities in delusional disorder.
• To compare potential risk factors, clinical correlates, illness course, and functionality between men and women with DD.

Main Methods:

• A sample of 86 outpatients diagnosed with delusional disorder (DD) was assessed.
• Utilized a battery of instruments including SCID-I, SAP, PANSS, MADRS, MMSE, MINI, SDI, and GAF scale.
• Compared demographic, personality, symptom, and functional data between genders.

Main Results:

• Men showed a higher prevalence of schizoid/schizotypal premorbid personality disorders and substance abuse.
• Men experienced earlier onset, more acute onset, and more severe symptoms (higher PANSS scores).
• Men exhibited significantly poorer global and partial functioning (work, family, social) compared to women.

Conclusions:

• Men with DD present with more severe symptomatology and impaired functionality.
• Gender-specific risk factors, including premorbid personality and substance abuse, are more prevalent in men.
• Findings highlight the need for gender-informed approaches in managing delusional disorder.