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Updated: Jun 14, 2026

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
Published on: November 17, 2018
[Effect of ozone water on the inflammation and repair in infected wounds]
Hua-jun Huang1, Bin Yu, Qing-rong Lin
1Department Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objective:
To study the effect of ozone water in promoting the healing of infected wounds.
Methods:
Fifty Wistar rats were randomly divided into 5 groups, namely chlorhexidine treatment group, 5, 10, and 20 mg/L ozone water treatment groups, and the control group without any treatment. Infected wounds were induced on the back of the rats, and at 48 h of infection, chlorhexidine or ozone water was applied once daily for 9 days. Before and at days 3, 6, and 9 of the treatment, the wound changes were observed. The WBC in the tail venous blood was detected and the incised skin and muscular tissues were pathologically examined. RESULTS AMD CONCLUSION: Ozone water showed better effects in promoting the healing of the infected wound, especially at higher doses of 10 and 20 mg/L.
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