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Published on: October 14, 2016
A paraneoplastic membranoproliferative glomerulonephritis with isolated C3 deposits associated with hairy cell
Imad Abboud1, Lionel Galicier, Adrienne De Labarthe
1Nephrology, Saint Louis Hospital, 1 Avenue Claude Vellefaux, 75010 Paris, France. imad.abboud@sls.aphp.fr
Abstract:
We describe a 35-year-old woman who presented with proteinuria and microscopic haematuria. Blood tests revealed a low C3 complement level, with no evidence of cryoglobulin. Renal biopsy showed a Type 1 membranoproliferative glomerulonephritis (MPGN) with isolated C3 deposits on immunofluorescence study. Bone marrow aspirate, done for monocytopenia, was consistent with a diagnosis of hairy cell leukaemia (HCL). Both haematological and nephrological diseases completely responded to treatment with cladribine, strongly suggesting that the renal disease was a paraneoplastic syndrome. To our knowledge, this is the first report of a non-cryoglobulinaemic MPGN associated to HCL.
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