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Synthesis and anthelmintic activity of 3'-benzoylurea derivatives of
R J Weikert1, S Bingham, M A Emanuel
1Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
Journal of Medicinal Chemistry
|May 1, 1991
Abstract:
Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a series of benzoylureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2,6-difluoro and 4-trifluoromethyl substituents had potent nematocidal activity in both mice and sheep. No antiectoparasitic activity was observed.