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Published on: March 6, 2018
Vitamins and prostate cancer risk.
Krishna Vanaja Donkena1, R Jeffrey Karnes, Charles Y F Young
1Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Vitamins like A, B, C, D, and E show anti-cancer properties in lab studies. However, their effectiveness in preventing or treating human prostate cancer requires further investigation.
Area of Science:
- Oncology
- Nutritional Science
Background:
- Prostate cancer (PC) is a significant global health concern for men.
- Effective prevention and treatment strategies for PC are still under development.
Purpose of the Study:
- To review the current understanding of the relationship between various vitamins and prostate cancer risk.
- To synthesize findings from laboratory, epidemiological, and clinical studies on vitamin effects in PC.
Main Methods:
- Literature review of existing research on vitamins and prostate cancer.
- Analysis of data from in vitro studies, animal models, epidemiological surveys, and clinical trials.
Main Results:
- Several vitamins (A, B, C, D, E) and retinoids exhibit potential anti-cancer activities, acting as antioxidants, transcription factor activators, or epigenetic modifiers.
- Laboratory and animal studies suggest possible anti-PC properties for these vitamins.
- The efficacy of vitamins in preventing or treating human PC remains largely undetermined and requires extensive study.
Conclusions:
- Vitamins possess demonstrated anti-cancer mechanisms relevant to prostate cancer.
- Further rigorous human studies are essential to confirm the preventative or therapeutic roles of vitamins in prostate cancer.
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