Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioreactor Controls-III01:22

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Gene Regulation During Sporulation01:17

Gene Regulation During Sporulation

Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foundations of Gerophysics.

Aging·2026
Same author

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging.

Aging cell·2026
Same author

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.

GeroScience·2026
Same author

Past, present and future perspectives on the science of aging.

Nature aging·2026
Same author

The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Lessons on longevity from budding yeast.

Matt Kaeberlein1

  • 1Department of Pathology, University of Washington, Seattle, Washington 98195, USA. kaeber@u.washington.edu

Nature
|March 26, 2010
PubMed
Summary
This summary is machine-generated.

Budding yeast research has significantly advanced understanding of the ageing process. Key findings from yeast longevity studies are leading to potential interventions and drug candidates for slowing human ageing.

More Related Videos

Measuring Replicative Life Span in the Budding Yeast
12:41

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
12:24

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

Related Experiment Videos

Last Updated: Jun 14, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Measuring Replicative Life Span in the Budding Yeast
12:41

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
12:24

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

Area of Science:

  • Gerontology and molecular biology
  • Yeast as a model organism for ageing research

Background:

  • Recent decades show fundamental advances in understanding ageing.
  • Budding yeast studies have been crucial in this progress.
  • Yeast longevity factors influence ageing across species.

Purpose of the Study:

  • To highlight the significant contributions of yeast research to ageing science.
  • To underscore the potential of yeast-derived findings for human anti-ageing interventions.

Main Methods:

  • Review of studies on yeast longevity factors.
  • Analysis of conserved ageing pathways between yeast and higher organisms.
  • Evaluation of yeast-derived anti-ageing drug candidates.

Main Results:

  • Yeast longevity factors have been shown to modulate ageing in invertebrate and mammalian models.
  • Studies in yeast have identified promising candidates for anti-ageing drugs.
  • Yeast serves as a powerful model for dissecting fundamental ageing mechanisms.

Conclusions:

  • The humble yeast has been instrumental in advancing ageing research.
  • Interventions to slow human ageing may emerge from yeast studies.
  • Yeast research provides a foundation for future anti-ageing therapeutic development.