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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

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Prehypertension and endothelial progenitor cell function.

O J MacEneaney¹, C A DeSouza, B R Weil

¹Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.

Journal of Human Hypertension

|March 26, 2010

Summary

This summary is machine-generated.

Prehypertension impairs endothelial progenitor cell (EPC) colony-forming capacity, but only in individuals with systolic blood pressure over 130 mmHg. This dysfunction in vascular repair cells was not linked to migration issues or increased cell death.

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Area of Science:

Cardiovascular Science
Cell Biology
Vascular Biology

Background:

Prehypertension is linked to vascular damage and cardiovascular events.
Endothelial progenitor cells (EPCs) are crucial for vascular repair and neovascularization.
The impact of prehypertension on EPC function remains unclear.

Purpose of the Study:

To investigate the effect of prehypertension on EPC function.
To assess EPC colony-forming capacity, migration, and apoptosis in normotensive and prehypertensive adults.

Main Methods:

Collected peripheral blood from 83 adults (40 normotensive, 43 prehypertensive).
Isolated and analyzed EPCs for colony-forming unit (CFU) capacity, migratory activity, and apoptosis.
Stratified prehypertensive groups into low (120-129 mmHg) and high (130-139 mmHg) systolic blood pressure categories.

Main Results:

No significant differences in EPC CFU, migration, or apoptosis were found between overall normotensive and prehypertensive groups.
EPCs from the high prehypertension group (systolic BP >130 mmHg) exhibited significantly reduced colony-forming capacity (~65% fewer CFUs) compared to low prehypertension and normotensive groups.
EPC migration and apoptosis were not significantly affected by prehypertension in any subgroup.

Conclusions:

EPC colony-forming capacity is impaired specifically in prehypertension with systolic blood pressure exceeding 130 mmHg.
Prehypertension, in general, does not appear to cause migratory dysfunction or increased apoptosis in EPCs.
These findings highlight a specific threshold of systolic blood pressure in prehypertension that impacts vascular repair cell function.