Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary cilia protect against intervertebral disc degeneration and spine scoliosis by regulating Hedgehog-P53-mediated cell apoptosis signaling.

Journal of advanced research·2026
Same author

Polydatin for treating spinal cord injury: Multiple mechanisms and challenges.

Journal of pharmaceutical analysis·2026
Same author

From molecular regulation to tissue repair: hydrogels in the fight against intervertebral disc degeneration.

Annals of medicine·2025
Same author

Anti-Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration.

Bioactive materials·2025
Same author

Minimally Invasive Unilateral Pedicle Combined With Contralateral Translaminar Facet Joint Screw Fixation for Single-Segment Lumbar Degenerative Disease: A 10-Year Follow-Up Study.

Spine·2024
Same journal

Biomechanical Performance of Zirconia-Calcium Silicate-Silver Hybrid Dental Crown Under Static and Transient Dynamic Loading: A Finite Element and TOPSIS-Based Multi-Criteria Evaluation.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Synthesis, Characterization, and Implantation of Ferulic Acid-Loaded Chitosan/Aloe vera Hydrogels in Rat Full-Thickness Wound Model.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Double-Crosslinked SIS-Derived Collagen/Alginate Hydrogel With Antibacterial and Pro-Regenerative Activities for Soft Tissue Repair.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Silver and Gold Nanoparticles Promote Antimicrobial Activity and Modulate Inflammation in Escherichia coli-Infected Wounds.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Injectable Thermosensitive Placental ECM-Copper Hydrogel With Endothelial Progenitor Cells for Pressure Ulcer Repair.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Strut Thickness and Species-Specific Healing Are Key Considerations in Developing Zinc-Based Biodegradable Arterial Stents.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Injectable bone cement based on mineralized collagen.

Xi Liu1, Xiu-Mei Wang, Zonggang Chen

  • 1State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|March 26, 2010
PubMed
Summary
This summary is machine-generated.

A new injectable bone cement using mineralized collagen, nano-hydroxyapatite/collagen (nHAC), and calcium sulfate hemihydrate (CSH) shows promising results for bone repair. This nHAC/CSH composite demonstrated superior biocompatibility compared to pure CSH cement in both lab and animal studies.

More Related Videos

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Related Experiment Videos

Last Updated: Jun 14, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Regenerative Medicine

Background:

  • Injectable bone cements are crucial for bone defect repair.
  • Current cements face limitations in biocompatibility and integration.
  • Mineralized collagen offers a promising scaffold for bone regeneration.

Purpose of the Study:

  • To develop and evaluate a novel injectable bone cement based on mineralized collagen.
  • To investigate the properties and biocompatibility of a nano-hydroxyapatite/collagen and calcium sulfate hemihydrate composite (nHAC/CSH).
  • To compare the performance of the nHAC/CSH cement with pure calcium sulfate hemihydrate (CSH) cement.

Main Methods:

  • Fabrication of the nHAC/CSH composite bone cement.
  • Assessment of cement workability and in vitro degradation.
  • Evaluation of in vitro and in vivo biocompatibility through comparative studies.

Main Results:

  • The nHAC/CSH composite cement exhibited favorable workability and degradation characteristics.
  • In vitro and in vivo studies indicated enhanced biocompatibility for the nHAC/CSH cement compared to pure CSH cement.
  • The composite cement demonstrated good integration and cellular response in biological environments.

Conclusions:

  • The novel injectable nHAC/CSH bone cement shows significant potential for bone repair applications.
  • Its improved biocompatibility makes it a promising alternative to conventional bone cements.
  • Further research is warranted to explore its full clinical utility in orthopedic procedures.