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Human bocavirus infection in children with acute respiratory tract infection in India

Preeti Bharaj1, Wayne M Sullender, Sushil K Kabra

  • 1Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Journal of Medical Virology
|March 26, 2010
PubMed

Insights

Human bocavirus (HBoV), a novel parvovirus, was detected in 7.2% of young children with respiratory infections in India. This virus is linked to both upper and lower respiratory illnesses, showing no seasonal pattern.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Human bocavirus (HBoV) is a recently identified human parvovirus.
  • HBoV has been associated with respiratory tract diseases in children.

Purpose of the Study:

  • To investigate the prevalence and clinical presentation of HBoV in young children with acute respiratory tract infections in India.

Main Methods:

  • Nasopharyngeal aspirates were collected from 305 children under 5 years old with acute respiratory tract infection.
  • Samples were screened for HBoV using two independent sets of polymerase chain reaction (PCR).

Main Results:

  • HBoV was detected in 22 children (7.2%), all presenting with acute respiratory infection.
  • The most common symptoms observed were cough (95%), runny nose (64%), and fever (59%).
  • HBoV was co-detected with respiratory syncytial virus in one case and influenza A virus in another.

Conclusions:

  • HBoV is prevalent in young children with respiratory infections in India.
  • HBoV is associated with both upper and lower respiratory tract diseases.
  • No seasonal distribution was observed for HBoV infections.

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